saffron supplements modulate serum pro-oxidant-antioxidant balance in patients with metabolic syndrome: a randomized, placebo-controlled clinical trial

Authors

tayyebeh kermani department of anatomy and cell biology, birjand university of medical sciences, birjand, iran.

seyyed hadi mousavi pharmacological research center of medicinal plant, faculty of medicine, mashhad university of medical science, mashhad, iran.

maryam shemshian biochemistry of nutrition research center, school of medicine, mashhad university of medical science, mashhad, iran.

abdolreza norouzy biochemistry of nutrition research center, school of medicine, mashhad university of medical science, mashhad, iran.

abstract

objectives: we have investigated the effect of a saffron supplement, given at a dose of 100 mg/kg, on prooxidant-antioxidant balance (pab) in individuals with metabolic syndrome. materials and methods: a randomized, placebo-controlled trial design was used in 75 subjects with metabolic syndrome who were randomly allocated to one of two study groups: (1) the case group received 100mg/kg saffron and (2) the placebo control group received placebo for 12 weeks. the serum pab assay was applied to all subjects before (week 0) and after (weeks 6 and 12) the intervention. results: there was a significant (p=0.035) reduction in serum pab between week 0 to week 6 and also from week 0 to week 12.  conclusion: saffron supplements can modulate serum pab in subjects with metabolic syndrome, implying an improvement in some aspects of oxidative stress or antioxidant protection.

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Journal title:
avicenna journal of phytomedicine

جلد ۵، شماره ۵، صفحات ۴۲۷-۴۳۳

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